Endocrine Abstracts

Introduction: Single nucleotide polymorphic variants of the methylenetetrahydrofolate reductase (MTHFR) gene have been related with a tendency to gain weight according to recent studies. The aetiology of atypical anorexia nervosa remains under investigation and might be associated with the genetic background. The aim of this study was to evaluate the association between the presence of A1298C or C677T polymorphisms of the MTHFR gene and weight status in a sample of adolescent ...

Introduction: Fine needle aspiration biopsy (FNAB) is the initial investigation of choice for thyroid nodules.Methods: A total of 563 patients (106 males/457 females) underwent FNAB for the same number of thyroid nodules. Their mean age was 56.1±14.1 years. We correlated the demographic profile (age and gender) and sonographic features of these nodules with the FNAB outcome. The Bethesda system for reporting thyroid cytopathology was used.<p cla...

Introduction: The aim of this study was to investigate the association between the genetic background of coagulation factors and the presence of oligo- or amenorrhea in adolescent girls diagnosed with anorexia nervosa compared with controls.Patients and Methods: A total of 40 adolescent girls diagnosed with anorexia nervosa aged 14–17 years, as well as 10 age-matched girls, were included in the study. We recorded anthropometric parameters and calcu...

BackgroundPituitary disease registries are major instruments of epidemiological and clinical data collection used worldwide.ObjectiveTo assess the data of pituitary tumor registry in Russia.Material and methodsPatient records, retrieved from online platform of the Registry.ResultsCurrently there are 9858 patients regis...

IntroductionSARS-CoV-2 has caused a global outbreak of coronavirus disease 2019 (COVID-19). It is known that this virus binds angiotensin-converting enzyme 2 (ACE2) of the renin-angiotensin system, which may exert substantial effects on sodium and potassium metabolism. Viral pneumonia and respiratory distress are well known etiologies for hyponatremia due to syndrome of inadequate secretion of antidiuretic hormone, and can worsen clinical course of the d...

Introduction: Research into autoimmune disorders associated with COVID-19 in the middle of an ongoing COVID-19 pandemic is an important and urgent challenge. We focus on the potential relationship between coronavirus infection and other autoimmune diseases, and the positive therapeutic effect of the treatment of severe forms of COVID-19 with drugs traditionally used in the treatment of rheumatological diseases. The results of this study are a starting point for understanding t...

Bone densitometry (DEXA) is the best method available today for diagnosing low bone density. However, DEXA is not able to differentiate osteoporosis from osteomalacia. The definitive diagnosis of osteomalacia is made by bone biopsy – rarely used in medical practice – which shows excess unmineralized bone. Tests of blood and urine may also be helpful: concentration of serum and urinary calcium and phosphorus, 25-hydroxyvitamin D and parathyroid hormone b...

The population of the world is aging and is estimated that by 2030 – 21% of global population will be aged 65 years and older. At present, under-nutrition in older people is a serious and growing global problem affecting even developed countries. As one ages, several physiological and pathlogical changes may contribute towards the development of protein energy malnutrition. This syndrom brings with it many adverse health outcomes and a significant cost to the individual, ...

Introduction: There is some variation in the practice of gonadectomy for individuals with Differences of Sex Development (DSD) worldwide. This quality improvement project aims to undertake continued surveillance of the occurrence of gonadectomy in suspected or confirmed cases of DSD.Methods: Participating centres from the International-DSD Registry are sent a monthly email asking if a gonadectomy has been performed. A se...

Systems Medicine is an interdisciplinary field of study that deals with systems of the human body as part of an integrated whole, incorporating biochemical, physiological, and environment interactions. Systems Medicine draws on systems science and systems biology, and considers complex interactions within the human body with a patient’s genomics, behavior and environment perspective. The earliest uses of the term systems medicine appeared in 1992, it is a modern approach ...